The study was aimed to evaluate the antiparkinsonism activity of the leaves of Caesalpinia mimosoides Lamk. The ethanolic extract of Caesalpinia mimosoides Lamk leaves were evaluated for the antiparkinsonism activity against rotenone induced parkinsonism rats. Behavioral assessments such as catalepsy, muscle rigidity and locomotor activity were noted. Phytochemical tests indicated the presence of alkaloids, steroids, carbohydrates, saponins, tannins, flavonoids and phenolic compounds. Oral administration of the test extract (200 mg/kg) were significantly reversed the rotenone induced changes in oxidative stress markers, histopathological changes and behavioral alterations, which indicates the antiparkinsonism activity of the test extract. In conclusion, the present study suggests that ethanolic extract of Caesalpinia mimosoides Lamk show beneficial effects in relieving symptoms of parkinsonism.
Loading....